侯雪龙  研究员 

中国科学院上海有机化学研究所

金属有机化学国家重点实验室,沪港化学合成联合实验室 

上海市零陵路345号,200032

电话: +86 21 54925144

传真: +86 21 54925100

邮箱: xlhou@sioc.ac.cn

学习经历:

1975 - 1978 上海第一医学院药学系

1980 - 1986 中国科学院上海有机化学研究所,研究生(导师:黄乃正教授与黄维垣研究员)

 

工作经历:

1978 - 1980 上海第一医学院药学系药化教研组,助教

1986 - 1987 中国科学院上海有机化学研究所,助研

1987 - 1989 德国科隆大学有机化学研究所,博士后(E. Vogel小组)

1989 - 1992 中国科学院上海有机化学研究所,助研

1992 - 1997 中国科学院上海有机化学研究所,副研究员

1997.9 -    中国科学院上海有机化学研究所,研究员

2006.7 - 2006.8  日本大阪大学访问教授

2010.2 - 2010.3  法国 Paul Sabatier大学访问教授  

研究领域:
  • 导向有机合成的金属有机化学
  • 配体设计
  • 不对称催化
  • 有机小分子催化

获奖及荣誉:
  • 德国洪堡奖学金(1987-1989)
  • 国家自然科学二等奖(1997年),第二完成人  
  • 上海市科技进步一等奖(2001年),第二完成人
  • 国家自然科学二等奖(2002年),第二完成人
  • Award of JSPS Invitation Fellowship Program for Research in Japan(2002年)
  • Eli Lilly Scientific Excellence Award in China (2005)
  • 入选“上海市领军人才”(2007)
  • Peking University-Eli Lilly Lectureship (2009)

职务:
课题组长

代表论著:

1. Yan, X. X.; Liang, C. G.; Zhang, Y.; Hong, W.; Cao, B. X.; Dai, L. X.; Hou, X. L.*, Highly Enantioselective Pd-Catalyzed Allylic Alkylation of Acyclic Ketones, Angew. Chem. Int. Ed.  2005, 44, 6544-6546.

2. Xiao-Xia Yan, Qian Peng, Yan Zhang, Kai Zhang, Wei Hong, Xue-Long Hou* and Yun-Dong Wu, A Highly Enantio- and Diastereoselective Cu-Catalytic 1,3-Dipolar Cycloaddition of Azomethine Ylides with Nitroalkenes, Angew. Chem. Int. Ed. 2006, 45, 1979-1983.

3. Zheng, W.-H.; Zheng, B.-H.; Zhang, Y.; Hou, X.-L.*, Highly Regio-, Diastereo- and Enantioselective Pd-Catalyzed Allylic Alkylation of Acyclic Ketone Enolates with Monosubstituted Allyl Substrates, J. Am. Chem. Soc. 2007, 129, 7718-7719.

4. Zhang, K.; Peng, Q.; Hou, X.-L.*; Wu, Y.-D., Highly Enantioselective Palladium-Catalyzed alkylation of Acyclic Amides, Angew. Chem. Int. Ed. 2008, 47, 1741.

5. Wen-Qiong Wu, Qian Peng, Da-Xuan Dong, Xue-Long Hou* and Yun-Dong Wu*, A Dramatic Switch of Enantioselectivity in Asymmetric Heck Reaction by Benzylic Substituents of Ligands,J. Am. Chem. Soc. 2008, 129, 9717-9725.

6. Xiao Xia Yan, Qian Peng, Qing Li, Kai Zhang, Jun Yao, Xue Long Hou*, Yun Dong Wu*, Highly Diastereoselectivity Switchable Enantioselective Mannich Reaction of Glycine Derivatives with Imines, J. Am. Chem. Soc. 2008, 130, 14362-14363.

7. Wei Jing Lu, Yun Wei Chen, Xue Long Hou*, Iridium-Catalyzed Highly Enantioselective Hydrogenation of the C=C bond of α, β-Unsaturated Ketones, Angew. Chem. Int. Ed. 2008, 47, 10133-10136.

8. Wei Liu, Di Chen, Xia-Zhen Zhu, Xiao-Long Wan and Xue-Long Hou*, Highly Diastereo- and Enantioselective Pd-Catalyzed Cyclopropanation of Acyclic Amides with Substituted Allyl Carbonates, J. Am. Chem. Soc. 2009, 131, 8734-8735.

9. Lei, B.-L.; Ding, C.-H.; Yang, X.-F.; Wan, X.-L.; and Hou, X.-L.*, Highly Efficient Kinetic Resolution of 2-Substituted-2,3-Dihydro-4-Quinolones by Palladium-Catalyzed Asymmetric Allylic Alkylation, J. Am. Chem. Soc. 2009, 131, 18250-18251.

10. Hai-Lin Liu, Di Chen, Xue-Long Hou*, Michal Sabat, and Lin Pu*, Highly Enantioselective Recognition of Structurally Diverse a-Hydroxycarboxylic Acids by a Fluorescent Sensor, Angew. Chem. Int. Ed. 2010, 49, 602-606.